Metal homeostasis is the regulatory process by which organisms maintain a balance of essential metals such as iron, zinc, copper, and manganese within their cells. This balance is crucial for proper cellular function, as metals play important roles in processes such as enzyme catalysis, electron transport, and structural stability. Dysregulation of metal homeostasis can lead to various health problems, including neurodegenerative diseases, metabolic disorders, and cancer. Research in metal homeostasis focuses on understanding the mechanisms by which cells acquire, store, utilize, and detoxify metals. This includes studying the transport proteins involved in metal uptake and distribution, the regulatory pathways that control metal ion levels, and the cellular responses to metal toxicity. By elucidating these processes, researchers aim to develop new therapeutic strategies for diseases associated with metal imbalances and to improve our understanding of the role of metals in health and disease.